Aminata Ould El Hadj Khelil
Université Kasdi Merbah-Ouragla, Algeria
Title: Antioxidant, anti-lipase and anti-alpha amylase properties of water extracts of Anvillea radiata (Asteraceae)
Biography
Biography: Aminata Ould El Hadj Khelil
Abstract
Anvillea radiata (Asteraceae) is an endemic species of North Africa which is used in folkloric medicine for treating hypertension, gastro-intestinal ailments, genital diseases and diabetes mellitus. The aim of the present study was to evaluate some biological activities of water extracts of Anvillea radiata areal part. The water extracts of Anvillea radiata areal part were obtained in the same conditions like the traditional preparation modes (decoction and infusion). The antioxidant potential of water extracts was measured by three different assays: ferric reducing antioxidant power (FRAP) and scavenging activity on 2, 2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS•+) radical cation and on 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical. Moreover, lipase and alpha amylase inhibition assays of water extracts of Anvillea radiata were also evaluated. The contents of total phenolic (28.79±2.16 mg GAE/g of dry weight), flavonoids (16.37±1.45 mg RE/g DW) and condensed tannins (8.02±0.72 mg CE/g DW) were found significantly higher in decoction than in infusion. The IC50 values based on the FRAP (21.39±1.08 µg/ml), ABTS (73.92±6.47 µg/ml) and DPPH (14.90±0.38 µg/ml) were lower in comparison with standard antioxidants (butylated hydroxytoluene, trolox) showing potential antioxidant properties. Lipase and alpha amylase inhibition assays proved that the inhibition rate of decoction varied respectively from 78.95% and 81.54% to 29.33% and 31.76% from the highest (8 mg/ml) to the lowest concentration (0.5µg/ml). In conclusion, the present results revealed that Anvillea radiata has hypoglycemic and anti-obesity properties.