Imran Ali Khan Mohammed
King Saud University, KSA
Title: Relationship between the paraoxonase 1 gene Glutamine 192 to Arginine polymorphism and Gestational Diabetes Mellitus in Saudi women
Biography
Biography: Imran Ali Khan Mohammed
Abstract
In Gestational Diabetes Mellitus (GDM) there is a disturbance between insulin resistance and insulin secretion, and this leads to maternal hyperglycemia. There are reports in Saudi population which indicated a high frequency of Paraoxonase 1 glutamine 192 to arginine (PON1 Q192R) polymorphism, which suggested polymorphism to be an additional risk factor. The present study aimed to observe the possible association between the PON1 Q192R polymorphism and GDM. The case–control study was carried out in pregnant women. We did the genotyping for PON1 Q192R (rs662) variants. Q192R polymorphism was significantly associated with GDM with the minor allele frequency (MAF). Q192R genotypes and alleles showed a strong association with GDM. Thus, we opine that PON1 Q192R polymorphism has high MAF in GDM in the studied population.