Christain Dani
French National Institute for Health and Medical Research, France
Title: Human Induced Pluripotent Stem cells: A new source for brown and white adipocytes
Biography
Biography: Christain Dani
Abstract
Mesenchymal Stem Cells (MSCs) derived from human induced Pluripotent Stem Cells (hiPSCs) provide a novel source for generating adipocytes, thus opening new avenues for fundamental research and clinical medicine. We present the adipogenic potential of hiPSCs and the various methods to derive hiPSC-MSCs. We discuss the main characteristic of hiPSC-MSCs, which is their low adipogenic capacity as compared to adult-MSCs. Finally, we propose several hypotheses to explain this feature, underlying a potential critical role of the micro-environment. We favor the hypothesis that the range of factors or culture conditions required to induce adipocyte differentiation of MSCs derived from adult tissues and from embryonic-like cells could differ.
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