Christain Dani
French National Institute for Health and Medical Research, France
Title: Human adipocyte progenitors: Proliferation and differentiation in the obesity context
Biography
Biography: Christain Dani
Abstract
Adipose tissue expansion is well-orchestrated to fulfill the energy demand. A pool of adipocyte progenitors (APs) isrnresponsible for the formation of new adipocytes and for the potential of this tissue to expand in response to chronic energyrnoverload. However, molecular mechanisms controlling proliferation and differentiation of human APs are largely unknown. Chronic low grade inflammation and hypoxia take place in obese and diabetic adipose tissue microenvironment. We willrndiscuss the role playing by the TGFb family members in human adipogenesis. We will show that macrophages that are locatedrnin obese adipose tissues regulate AP self renewal through activin A. The immediate early response 3 gene (IER3) is required forrnAP proliferation and differentiation and IER3 expression is a common target of activin A and hypoxia. Altogether, we proposerna model in which changes in the obese adipose tissue lead to expansion through activin A and IER3 that are potential targetsrnfor controlling the size of AP pool in adipose tissue.
