Pedro Parra Caballero
Hospital Universitario La Princesa, Spain
Title: Evaluation of the impact of abdominal Obesity on glucose and lipid metabolism disorders in adults with Down syndrome
Biography
Biography: Pedro Parra Caballero
Abstract
OBJECTIVES: To describe anthropometric differences in weight-related disorders between adults with Down syndrome (DS) and healthy controls, as well as their disparate impact on glucose and lipid metabolism disorders. MATERIAL AND METHODS: cross-sectional study of 49 consecutively selected, community-residing adults with DS and 49 healthy controls in an outpatient clinic of a tertiary care hospital; siblings of adults with DS were studied as controls in 42 cases. Epidemiological, anthropometric, clinical and laboratory data were measured. RESULTS: Adults with DS had a higher prevalence of overweight, obesity and abdominal obesity than controls, along with a higher waist-to-height ratio (WHR), but total body fat percentage and lipidic profile were similar between groups. HOMA indexes were higher in adults with DS, and especially in those presenting abdominal obesity (HOMA-IR 3.48 vs. 1.41; HOMA-b 164.4 vs. 82.3; p < 0.05 for both comparisons). DISCUSSION AND CONCLUSIONS: Weight-related disorders were highly prevalent among adults with DS. Adults with DS and abdominal obesity showed the highest insulin resistance indexes, which were higher than those of adults with DS but no abdominal obesity and than those of controls with abdominal obesity. We found a significant relationship between abdominal obesity and insulin resistance in adults with DS, and a relatively low prevalence of metabolic syndrome among adults with DS and abdominal obesity. Favorable leptin/adiponectin balance
