Samar Rachidi
Lebanese University, Lebanon
Title: Association of oxidative stress induced by Iron status to the risk of Gestational Diabetes Mellitus- A pilot study
Biography
Biography: Samar Rachidi
Abstract
We aim to evaluate the role of elevated oxidative stress mediated by iron stores as a predictive factor for gestational diabetes mellitus (GDM) risk. Iron status was evaluated by ferritin levels at early pregnancy and biological markers of oxidative damage were assessed between 24 to 28 weeks of gestation at the time of GDM diagnosis in 93 non-anemic and non iron-supplemented pregnant women. We carried out a stratified analysis for biological markers of oxidative damage and redox status, to set if these variables are associated with gestational diabetes mellitus in strata of ferritin <13 µg/L and ferritin ≥38.5 µg/L (the lowest and the highest quartile of ferritin values). Our results showed that ferritin was a modifying factor for the correlation of glutathione reductase (rho=0.545; p=0.005) and Plasma thiobarbituric acid reactive substances TBARS (rho=0.432; p=0.031) with glucose intolerance. Increased iron stores could be a predictive factor for the risk of GDM. Iron supplementation could be avoided in women without diagnosed anemia.
