Biography:

Ould el Hadj-khelil A has completed his PhD from Rennes 1 University. Currently, she is a Professor of Biology and Research Director in the Department of Biology at Kasdi Merbah University of Ouargla. She is the Chair of Scientific Council in Natural and Life Sciences Faculty of Ouargla University. She is the Algerian responsible of PHC Tassili project code 11DMU 822. She participates in many scientific manifestations as member and as chair. She has more than 29 communications. She has published more than 18 papers in national and international journals.

Abstract:

Anvillea radiata (Asteraceae) is an endemic species of North Africa which is used in folkloric medicine for treating hypertension, gastro-intestinal ailments, genital diseases and diabetes mellitus. The aim of the present study was to evaluate some biological activities of water extracts of Anvillea radiata areal part. The water extracts of Anvillea radiata areal part were obtained in the same conditions like the traditional preparation modes (decoction and infusion). The antioxidant potential of water extracts was measured by three different assays: ferric reducing antioxidant power (FRAP) and scavenging activity on 2, 2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS^•+) radical cation and on 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical. Moreover, lipase and alpha amylase inhibition assays of water extracts of Anvillea radiata were also evaluated. The contents of total phenolic (28.79±2.16 mg GAE/g of dry weight), flavonoids (16.37±1.45 mg RE/g DW) and condensed tannins (8.02±0.72 mg CE/g DW) were found significantly higher in decoction than in infusion. The IC₅₀ values based on the FRAP (21.39±1.08 µg/ml), ABTS (73.92±6.47 µg/ml) and DPPH (14.90±0.38 µg/ml) were lower in comparison with standard antioxidants (butylated hydroxytoluene, trolox) showing potential antioxidant properties. Lipase and alpha amylase inhibition assays proved that the inhibition rate of decoction varied respectively from 78.95% and 81.54% to 29.33% and 31.76% from the highest (8 mg/ml) to the lowest concentration (0.5µg/ml). In conclusion, the present results revealed that Anvillea radiata has hypoglycemic and anti-obesity properties.

Biography:

Geetendra Singh Dhanawat is an eminent Diabetologist (Mumbai, India), completed his PG from CMC Vellore in Family Medicine & MPH from Global University Kohima. He is a Fellow of Royal Society of Public Health and completed his Fellowship in Intensive Care Medicine from Apollo Medvarsity. He has special interest in Diabetes and Disease Prevention. He completed PG Diabetology from John Hopkins University School of Medicine and Stonebridge University UK. He is a Strategic Diabetologist and Trainer at Connect & Heal Healthcare venture, a preventive care orientated organization. He has published several papers in reputed journals including Journal of WAO (World Allegy Organisation).

Abstract:

Prediabetes is a transition phase and is actually the golden period for physicians to reverse the diabetes progression upto a level. Besides diabetes, the other disorders like mild to moderate hypertension, lipid de-arrangements (low HDL, high to normal LDL, high TG, high VLDL and normal total cholestrol) and weight gain is associated in prediabetic phase. Functional foods are those food items which naturally have the power to heal beyond their nutritional value i.e. flax seeds, fenugreek, oats, apple, blueberries, garlic (alium sativum), broccoli, tomatoes, onion, red rice and guava fruit etc. In a trial at OPD basis, we advised 101 day functional food & lifestyle modification program to all pre-diabetic patients (53 patients with HbA1c level more than 5.7 but less than 6.5, out of these 19 have grade one hypertension) and we monitored them closely for proper compliance. Besides functional food plan, the patients also advised for specific exercise plans which includes aerobics, resistance exercise and yoga for stress management. At the end of 151 day functional food plan, we succeded to reverse prediabetes in 67% patients and also achieved reduction of blood pressure to 47% patients. During this plan, we never used any medication. The mean HbA1c after the end of program was 5.3%. (4.9%-5.4%). The functional food in diet are natural agents to prevent or delay diabetes. 

Biography:

Telli A is Assistant Master of Biochemistry in the University of Ghardaïa. She is responsible of Pedagogic Commission of Biochemistry. She is a member in the Franco-Algerian project of PHC TASSILI code 11DMU 822. She has more than 10 communications. She has published more than 8 papers in national and international journals. 

Abstract:

In the Algerian traditional medicine, the seeds of Ammodaucus leucotrichus (Apiaceae) are used to treat gastro-intestinal ailments, hypertension and diabetes. However, the hypoglycaemic activity of this species has not been investigated.  This study is undertaken to evaluate antioxidant and in vitro hypoglycaemic activities of aqueous extracts of Ammodaucus leucotrichus seeds. The aqueous extracts were obtained in the same conditions as traditional mode of preparation (decoction and infusion) and tested for preliminary phytochemical analysis. Some phenolic compounds (total phenolics, flavonoids, phenolic acids and condensed tannins) were quantified.  In addition, antioxidant and alpha amylase inhibitory assay were performed in the aqueous extracts of Ammodaucus leucotrichus seeds. Secondary metabolites such as phenolic compounds, flavonoids, condensed and hydrolysable tannins, saponin, alkaloids, terpenoids, steroids and glycosides were present in the aqueous extracts as well as some primary metabolites like proteins and reducing sugar. The obtained results showed that the infusion is the richest water extract in phenolic compounds and presents the most important antioxidant activity (IC₅₀=175.67±2.36 µg/ml for ABTS assay and IC₅₀=232.89±19.28 µg/ml for DPPH assay) in comparison with decoction and standards (BHT and Trolox). Also, the infusion exhibited up to 68.83% of inhibition of alpha amylase enzyme with IC₅₀=2.65 mg/ml. In conclusion, the water extracts of Ammodaucus leucotrichus seeds have strong antioxidant and alpha amylase inhibition action confirming its enthopharmacological use.

Biography:

Deepti Arha has completed her Master’s in Microbiology and is pursuing her PhD from CSIR’s prestigious institute on Drug Research, CSIR-Central Drug Research Institute. She has qualified national exams for fellowship like CSIR-JRF, ICMR-JRF and Graduate Aptitude Test with 94 percentile. She has published five papers in international journals. Except working in drug development, she is also working in the field of Gut Dysbiosis and Insulin Resistance.

Abstract:

Worldwide occurrence of insulin resistance is around 20% of human population and it is primarily linked to type 2 diabetes. Insulin resistance is associated with blunted response of insulin in peripheral tissues like skeletal muscle, adipose tissue and liver. Therapeutic approaches with natural product lay an excellent foundation for search of effective, relatively safe and inexpensive treatment options for diabetes mellitus and associated metabolic disorders. In search of novel compounds to ameliorate insulin resistance, we synthesized a derivative of isoalantolactone that increase glucose uptake in skeletal muscle cells dose dependently through increasing the translocation of GLUT4 to the cell surface. Compound exhibit its effect by augmenting the phosphorylation of AMPK. Activation of downstream AMPK signaling was confirmed by enhanced phosphorylation of ACC and SREBP-1c. The compound significantly ameliorates TNFα-induced insulin resistance in L6 myotubes. Moreover, when studied by CLAMS in db/db mice, it improved VO2, VCO2 and respiratory exchange ratio. There was a marked improvement in blood glucose as observed in oral glucose tolerance test. Treatment with the compound significantly increase energy expenditure by heat generation compared to control. There is an increase in mitochondrial genes like COX IV and cytochrome C. The compound significantly decreases serum cholesterol and increase clearance of triglyceride from the liver thus combating obesity induced insulin resistance and type 2 diabetes.

Biography:

Narges Malih has completed her MD from Kurdistan University of Medical Sciences (Iran) and residency studies from Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Abstract:

Objective: The aim of our study was to determine the frequency of high risk individuals in non-diabetic people with a family history of diabetes in their first degree relatives for diabetes and pre diabetes based on American Diabetes Association (ADA) and Centers for Disease Control and prevention (CDC) guidelines.

Method: We conducted a cross-sectional study in health care facilities with diabetes prevention and treatment units in north health network of Tehran, the capital of Iran. The inclusion criteria were diabetes free adults who were ≥20 years, had a family history of diabetes in at least one first degree family member and not being pregnant for women. This study concluded 408 participants.

Results: About 20% of participants were male. Based on ADA diabetes risk test, mean (SD) score was 3.09 (1.45) and 62 (16.8%) of participants had scored more than five so were in a high risk group for developing diabetes. Women and men ADA score was 2.9±1.49 and 3.6±1.14, respectively (p<0.001). Using pre diabetes risk assessment demonstrated 187 (50.5%) in low risk and 132 (33.2%) in high risk groups. There was no significant difference between two sexes (p>0.05).

Conclusion: About 17% and 33% of healthy persons with a family history of diabetes were in high risk groups for diabetes and pre diabetes, respectively.